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I livelli plasmatici di sertralina sono aumentati di circa il 50% in soggetti scarsi metabolizzatori dell’enzima CYP 2C19 rispetto ai soggetti considerati rapidi metabolizzatori del CYP 2C19 (vedere paragrafo 5.2). Save 20% and free shipping with the code DAVIS14. In healthy subjects, no difference was observed between CYP2D6 extensive metabolizers (EMs) and poor metabolizers (PMs) with respect to oral clearance or elimination half-life.